Findings in 67 patients With tuberous sclerosis

Manuscript accepted for publication November 12, 2008. Abstract. Background. Tuberous sclerosis is an uncommon neurocutaneous syndrome characterized by the appearance of hamartomas in multiple organs. Diagnosis is based on clinical criteria. Objective. To report the clinical findings in a series of 67 patients with tuberous sclerosis. Material and methods. This was a descriptive and observational retrospective study of patients with tuberous sclerosis referred to our dermatology clinics between January 1994 and March 2007. Results. All patients presented neurological or dermatological disorders. Other disorders, in descending frequency, were psychiatric (55.5 %), renal (32.8 %), cardiac (22.4 %), skeletal and pulmonary (13.4 %), and ophthalmological (11.9 %). Conclusions. We report the clinical findings in a series of patients with tuberous sclerosis. According to our literature search, this is the first such study in the Spanish population. Overall, our findings support those already published.